F91 Dudelange qualified for the 2018–19 UEFA Europa League, becoming the first club from the country to reach the group stage of a European competition.

In the competition Dudelange became the first club in Luxembourg's history to reach the second qualifying round, after a remarkable victory over NK Zrinjski (they lost 0–1 at home in the first leg, in the second leg they scored a goal in the 3rd minute of stoppage time to equalize on aggregate, and then scored 3 more goals in extra time).

In 2018, F91 Dudelange became the first Luxembourgish team to reach the group stage of a major European competition, after defeating CFR Cluj 5–2 on aggregate in the UEFA Europa League play-off round.

[2] Due to Dudelange's apparent underdog status, daily newspaper Gazeta Sporturilor regarded CFR's elimination as "the biggest shame in the history of Romanian football".

The men from the Grand Duchy were drawn into a 'Group of Death', containing European powerhouses Milan, Olympiakos and Spanish side Real Betis.

The Luxembourgers did, however, managed to pick up a famous and hard-fought point, on the last matchday, when they drew 0–0 against Real Betis at the Stade Josy Barthel.

[citation needed] In 2019, Dudelange qualified for the Europa League group stages for the second successive season after defeating FC Ararat-Armenia in the play-off round in a penalty shootout.