[2] The club was founded in 1907 as Jeunesse la Frontière d'Esch in reference to the proximity of their stadium to the border with France.

This is a national record, unless Racing FC Union Luxembourg's many predecessor clubs are counted together (they won a total of 28, divided between six incarnations).

Their most famous result came in the early stages of the 1973 competition when they held then-UEFA Cup holders Liverpool to a 1–1 draw at home before losing the second leg 2–0 at Anfield.

Jeunesse have continued their success into recent times, being one of the top three Luxembourgish clubs, along with F91 Dudelange and FC Etzella Ettelbruck, of the past few years.

Jeunesse Esch is the only club from Luxembourg to have reached the second round of the European Cup, and it has achieved that feat on two occasions, both under the leadership of George Berry in the early years of the competition: Overall, Jeunesse's record in European competition reads: Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.