In 2021, club owner Nicholas Mendola announced the launch of a women's soccer team, which started play in May.

[3] On May 9, 2022, the team announced that they would play their home games for the 2022 season at Dobson Field on the campus of D'Youville University while All-High Stadium is renovated.

[4] The club again only lost once in the regular season, then winning a pair of playoff games to reach the National Championship weekend.

FC Buffalo would fall against Calgary Foothills WFC in the semi-finals, ending their playoff run.

[9] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.