The club was formed in 1920 and currently play their home matches at the Stade Parsemain in Fos-sur-Mer, a commune in the Arrondissement of Istres.

During the Aviet-Korac years, the club advanced from France's lower amateur regional divisions all the way up to Ligue 2.

However, on 11 July 2014, following the reversal of a ruling against Valenciennes, Istres' relegation was confirmed, and they returned to the Championnat National.

On 12 March 2016, it was renamed Istres Football Club, with President Alain Christmann explaining, "The entity 'Ouest Provence' no longer exists, so this change is more logical.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.