FC Twente made its European debut in the 1968–69 Inter-Cities Fairs Cup, following a strong domestic campaign.
Their biggest achievement came in the 1974–75 UEFA Cup, where they advanced to the final after defeating teams like Juventus and Dukla Prague.
FC Twente participated in various European competitions throughout the decade but failed to replicate its earlier success.
FC Twente continued participating in European competitions but struggled to advance beyond the group stages.
After a period of absence, Twente returned to European football in the 2022–23 UEFA Europa Conference League.