Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development.

FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.

During the limb development Tbx4/Tbx5 stimulate the production of FGF10 in the lateral plate mesoderm where it will create an epithelial-mesenchymal FGF signal with FGF8.

Therefore, all branching morphogen organs such as the lungs, skin, ear and salivary glands required the constant expression of FGF10.

The mice showed no developing organs such as lungs, salivary glands, kidney or definitive limbs once autopsied.