This is partially explained by numerous gene-poor regions that display a remarkable degree of non-coding and syntenic conservation with non-mammalian vertebrates, suggesting they are functionally constrained.

[4] Because chromosome 5 is responsible for many forms of growth and development (cell divisions) changes may cause cancers.

[5] The following are some of the gene count estimates of human chromosome 5.

Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction).

So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.