[2] FNB's market coverage spans several major metropolitan areas, including Pittsburgh, Pennsylvania; Baltimore, Maryland; Cleveland, Ohio; Washington, D.C.; Charlotte, Raleigh, Durham and the Piedmont Triad (Winston-Salem, Greensboro and High Point) in North Carolina; and Charleston, South Carolina, with approximately 350 offices.

As of 2003, the company had grown to assets of $4.6 billion with more than 125 banking offices and began trading common shares on the New York Stock Exchange under the ticker symbol FNB.

Current chief executive officer Vincent J. Delie, Jr., joined the bank in 2005 as president of the Pittsburgh Region.

[8] FNB's growth in Pittsburgh has expanded from a single banking office in 1997 to nearly 100 locations and a top three retail deposit market share today.

[13] FNB, the Pittsburgh Penguins, Clay Cove Capital and The Buccini/Pollin Group broke ground on the project on September 1, 2021.

[23] In June 2022, FNB announced the purchase of UB Bancorp of Greenville, North Carolina, with $1.2 billion in assets and 15 Union Bank branches, for stock valued at $117 million.

In 2011, Delie became president of FNB Corporation and in 2012 he was additionally named chief executive officer and elected to the board of directors.

Delie reassumed his role as president of First National Bank when John Williams retired from the position in 2015.