ETR 450 (ElettroTrenoRapido 450) was the first series Italian tilting train (also called Pendolino).

The ETR 450 were in use on the Rome-Bari, Rome-Ancona-Rimini and Genoa-Florence - Rome lines.

In 2004, shortage of gyroscopic tilting controls (now out of production by British Aerospace) resulted in a decision to deactivate the tilting mechanism in the ETR 450.

This necessitated a reclassification of the ETR 450, placing it in the same category as most conventional passenger rail, and requiring a decrease in its speed on turns.

In December 2014, the last of the ETR 450 trains were removed from service, the later years of the model marked by operational delays and maintenance.