Rampelli graduated in Architecture at the University of Rome "La Sapienza" and worked as an architect.

[1] In his youth, hRampelli joined the Roman Youth section of the Italian Social Movement and in 1989, together with Gianni Alemanno, he was arrested for protests in Nettuno for the arrival of George H. W. Bush.

He joined later The People of Freedom and subsequently, in 2012, he followed Giorgia Meloni into Brothers of Italy.

He has been chairman of the FdI's parliamentary group from 2014 to 2018, when he has been elected vice-president of the Chamber of Deputies.

[2] In 2023, Rampelli proposed a law that would outlaw the use of any language other than Italian on official documents.