The area's construction took place in Victorian times alongside nearby landmarks Holborn Viaduct and Fleet Valley Bridge.

In 2010, Fabric briefly went into administration after its sister club Matter, with whom it had a cross-guaranteed loan, announced it would close for the summer due to financial difficulties suffered as a consequence of continued delays with TfL upgrade of the Jubilee Line.

[16][17] On 21 November 2016, Fabric and Islington Council reached agreement that the club could reopen with stricter conditions: a new photo identification system, covert surveillance, a lifetime ban for anyone found dealing or possessing illegal drugs, and no under-19s allowed between Friday 8pm to Monday 8am.

[18] Shortly after these changes were made, it was announced that Fabric would halve the number of "FABRICLIVE" bass-driven nights, which included their famous Playaz drum and bass residency, which spiked controversy among fans.

[20] Saturday nights, (known simply as "Fabric") showcase genres such as house, techno and disco, and feature the club's resident DJs Craig Richards and Terry Francis.

Richards was also one of the Directors of Music Programming, selecting the line-ups for Saturday nights, which have featured appearances by DJs such as Ricardo Villalobos, Carl Craig, Ellen Allien, and many others.

The music policy is underground house and techno, with the occasional live PA.[citation needed] A CD series was launched in 2001 under Fabric Records.