He made his Serie B debut on 13 April 1997, replacing Filippo Masolini in the final minutes.
[1] Since 1997–98 season he was loaned to Serie C2 teams Catanzaro, Fiorenzuola and Imperia.
He only played 7 times before transferred to Alzano in January 2002, as the club bought Spezia's half.
In June 2002 Genoa gave up the remain 50% registration rights to Alzano.
Since 2003–04 season Anzalone played for Ravenna Calcio, winning promotion play-offs in 2005 (partnered with Marco Bianchi as centre-backs)[2][3][4][5] and after two seasons in Serie C1, promoted to Serie B in 2007 as Group B champion.