The face of the giant panda sign, panda sign of the midbrain or double-panda sign is a characteristic "panda's face" appearance in magnetic resonance imaging (MRI) images of people with Wilson's disease.

Along with Kayser–Fleischer rings, the sign is helpful in diagnosis.

[1] While the sign is most common in Wilson's disease, it has been rarely reported in acute disseminated encephalomyelitis,[2] rabies encephalopathy,[3] toxic leukoencephalopathy[4] and Leigh syndrome.

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