Students of the Faculty of Science participated in the demonstration that lead to the events that ended the rule of communists in Czechoslovakia.

[3][4][7][8] During the COVID-19 pandemic, several experts from the Faculty of Science became well known in the Czech Republic, including Jaroslav Flegr,[9][10][11] Václav Hořejší,[11][12] and Dagmar Dzúrová.

[13][14] The Faculty of Science of Charles University is engaged in research in a wide range of environmental, geological, chemical and biological disciplines.

[15] In recent years, around 640 articles in international journals have been published annually by the staff and students of the Faculty of Science.

[16] In its materials, the faculty states that in recent years the number of articles published in impact periodicals has been increasing.

The research goals of the biological section are "ecological processes in the evolution of model groups of organisms" and "signalling and molecular mechanisms of cellular response", the goals of the chemical section are "new molecular systems for advanced health-beneficial and environmentally friendly applications", the research project of the geographical section is called "geographic systems and risk processes in the context of global changes and European integration" and the geological research project is "mechanisms of substance transport in the upper spheres of the earth".