He is the son of Dr. Jorge Arana Tagle, lawyer specializing in Maritime Law, and Mathilde von Bernard, athlete and former hockey player.

At 17 he was diagnosed with cancer called Hodgkin's disease, a malignancy of the lymphoid tissue that is located in the lymph nodes, spleen, liver and bone marrow.

In 2012 Facundo Arana came to try to climb Everest: 8,848 meters above sea level, in the middle of the Himalayas, to raise public awareness about the importance of solidarity and donating blood.

Some of these series were successes not only in Argentina but also in countries like Russia, Israel, Romania, Poland and much of Latin America so that Facundo Arana gained international fame.

In 2000 he was the co-star of the comedy Buenos vecinos, where he acted alongside Hugo Arana, Moria Casán and Malena Solda.

His next protagonist was in the soap opera Yago, pasión morena with Gianella Neyra in the afternoon of Telefe, for which he obtained his first Martín Fierro Award for Best Leading Telenovela Actor.

In 2006 he starred a new soap opera by Pol-Ka, Sos mi vidaThe fiction became the most-watched of the year 2006 in Argentina and was transmitted internationally by different chains, having great success in Eastern Europe and the Middle East.

In 2011 he returns to the small screen, starring alongside Julieta Díaz the soap opera Cuando me sonreís, a production of RGB producer of Gustavo Yankelevich.

In September he gave a recital in La Trastienda Club with his band Facundo Arana & The Blue Light Orquestra, presented his second album "EN EL AIRE".

In 2017 he made presentations in several provinces with En el aire, in the middle of the year he premiered in theater Los Puentes de Madison at Paseo La Plaza with Araceli González, which in 2018 led to Mar del Plata.

He also has moved his acting career towards this target, with Vidas robadas and Poder se puede with which he traveled in the most isolated parts of Argentina.