Kafisha was responsible for organizing many suicide bombings and other attacks on Israelis and creating many explosive belts.
Though overshadowed by more publicity-friendly terrorists like Zakaria Zubeidi, Kafisha was instrumental in transforming Nablus into the "terror capital of the West Bank," and when he was killed the Brigades were already planning a wave of terror attacks against Israeli civil and military targets on the West Bank.
On July 17, 2006, a bomb attack in Nablus organized by Kafisha killed an Israeli soldier and wounded six others.
On August 31, 2006, Kafisha was killed during a random ambush by the Israeli 93rd "Haruv" battalion of the Kfir Brigade.
Kafisha's status placed him only behind the leaders of Hamas's Izz ad-Din al-Qassam Brigades, Mohammed Deif and Ahmed al-Jabari of the Gaza Strip in terms of notoriety in the Israeli intelligence wanted lineup.