During the reign of her father, she married Marcus Peducaeus Plautius Quintillus,[2] a Roman senator who later served twice as consul and as Augur, and who was a nephew of Roman emperor Lucius Verus (who had co-ruled with her father from 161–169 and through adoption was her uncle).
[3] The mother of Plautius Quintillus was Ceionia Fabia, sister of Lucius Verus.
During Commodus' reign, Fadilla and her family lived in a private palace on Capitoline Hill in Rome which was later bestowed by the later Roman emperor Elagabalus (218–222) as one of his mother's favorite residences.
According to Herodian (History of the Roman Empire 1.13.1), Fadilla warned Commodus about Marcus Aurelius Cleander, a Praetorian prefect, who was becoming too powerful.
With the help from one of her sisters, she uncovered and revealed a palace conspiracy aimed at the removal of Commodus in 189.