[3] In 241 AD her father was appointed the head of the Praetorian Guard by the Roman Emperor Gordian III.

[4][5] After becoming the head of the Praetorian Guard, Timesitheus "effectively governed the Empire for Gordian".

To replace him, Philip (Marcus Julius Philippus) became head of the Praetorian Guard, and quickly set to plotting to overthrow the young Gordian III.

[5] Tranquillina's husband, Gordian III, died in 244 AD under unclear, unknown circumstances, aged only 19.

[5] Tranquillina is believed to have outlived both her father and husband, however it is unclear what happened to her afterwards.