[4] Falkville was named for Louis M. Falk, a Prussian merchant who emigrated to the area in the late 1850s.

Falk opened a general store in what is now Falkville in 1859[5] and later became the town's first postmaster.

[4] The L&N Railroad was constructed through Falkville in the early 1870s, and a rail station opened in 1872.

[4] In 1936, the Works Progress Administration constructed a town hall for Falkville.

On April 24, 1955, an F4 tornado tore directly through the town, killing five and injuring 20.

[7] Two years later, on April 8, 1957, a long-tracked F3 tornado hit the southern part of town.

[9] The town is concentrated along U.S. Route 31, 5 miles (8 km) south of Hartselle.

Interstate 65 forms the eastern edge of the town, with access from Exit 322.

As of the 2020 United States census, there were 1,197 people, 392 households, and 260 families residing in the town.

The climate in this area is characterized by hot, humid summers and generally mild to cool winters.