[4] Priceville was settled in the 1820s and is named for the Price family, who played prominent roles in its early history.

The community remained sparsely populated until the 1950s, when the construction of Interstate 65 brought rapid economic expansion.

The Wheeler National Wildlife Refuge is situated between Priceville and Decatur.

The Tennessee River (Wheeler Lake) passes just north of Priceville.

[1] Ginhouse Branch runs through the center of town, flowing north to the Tennessee River.

As of the 2020 United States census, there were 3,512 people, 1,204 households, and 945 families residing in the town.