The creek's drainage basin accounts for approximately 12,476 acres (19.5 sq mi; 50.5 km2) of the larger Hudson Direct Watershed.

In the city of Poughkeepsie, 2.5 miles (4.0 km) of the Fall Kill were channelized by stone walls during the Great Depression.

[2] The Innis Dye Works building, dating to the 1830s, abuts the creek several hundred feet from its confluence with the Hudson River.

[3] The creek was an important source of industrial water power in the early 19th century, such as grinding materials to make dyes.

[4] The New York State Department of Environmental Conservation designates the creek as a "Class C" stream, meaning it is suitable for fishing.