[1] The story details the supervillain cabal the Intelligencia's evil plot, and the reaction of the various Hulks and supporting characters.

The storyline begins by revealing that MODOK is a part of a loose-knit cabal of scientists called Intelligencia (consisting of the Leader, Doctor Doom, Mad Thinker, Wizard, Egghead, and the Red Ghost).

[2] Red Hulk fights and kills Thunderbolt Ross at the behest of Bruce Banner, with whom he has formed an alliance.

He recalls how she saved him from Doc Samson and how they forced Wizard and his allies to stand back and how they went to Castle Doom to steal his time machine.

Later, after their calculations end in Banner killing The Leader, they use the time machine of the desert to see a future that they control.

Lyra then battles him and the Frightful Four, her future team members, until Red She-Hulk arrives and beats her until Wizard stops her.

[8] Lyra, after having her intelligence increased four levels by Bruce Banner, releases Jennifer Walters and explains that she joined the ranks of the Intelligencia to find her.

They are then attacked by Red She-Hulk and afterwards Jennifer tries to convince her to join them, believing she was being manipulated by the Intelligencia; however, she throws them off the Hellicarrier base.

Skaar (using Banner's teleporter) appears on the scene and takes on Doom, not to save his father, but to make sure he is the only one that will finally get to kill him.

Deciding to use his magic instead, Doom begins to succumb to a "poison pill" that was laced into the cosmic energy he absorbed from the Hulk robot, causing him to rapidly lose his intelligence and be unable to remember the spells he would need to kill them, or even how to use his armor.

During this battle, Red She-Hulk brutally beats Jennifer and snaps her neck with a cable, apparently killing her.

[10] Red Hulk travels to the Baxter Building to ensure that no casualties occurred during the Intelligencia's abduction of Reed Richards.

Meanwhile, Lyra takes her position in the Frightful Four (now consisting of her, Klaw, Wizard, and Trapster) to attack the Baxter Building following Thundra's betrayal.

[11] The two then head off to help the Avengers, who have been caught up in a struggle with the Red She-Hulk as she is attempting to abduct Hank Pym for the Intelligencia.

Banner is attempting to rescue Pym from abduction, but Pym has done a bit of research as the Scientist Supreme and can read Red Hulk's energy signature on Banner's cellular structure — proving that he and Red Hulk have met several times recently.

Since Pym does not trust Banner, he fights off his attempts to pull him out and goes toe-to-toe with the Red She-Hulk, who poisons him with another neural anesthetizer.

Banner has Amadeus Cho hijacks War Machine's armor to create a defibrillator pulse, bringing Pym back to stable condition.

Pym tries to turn into Giant Man but the anesthetizer forces him to shrink instead, giving Red She-Hulk the opportunity to grab him and teleport back to the Intelligencia, leaving only three more to capture, including Bruce Banner.

Banner gets an Avengers quinjet and hand-picks a group composed of Korg, A-Bomb, Namor, Spider-Man, Wolverine, and Cho.

Their mission is to rescue Reed Richards, Pym, Hank McCoy, T'Challa, and Betty Ross from the Intelligencia.

[13] Bruce Banner and Red Hulk separately attack the Intelligencia's Helicarrier, while Amadeus is trying to take Betty from Talbot.