The event follows Eddie Brock and his son Dylan who, after seeing glimpses of each other's potential future, engage in a war to determine who will be the one true Venom.
Various issues of the series are dedicated to deceased Marvel employees Ray Chan, Don Perlin, and John Cassaday.
Marvel released teaser art by Philip Tan showing Eddie Brock and Dylan Brock leading their symbiote armies in battle, with Agent Anti-Venom, Tyro, Wilde, Bedlam, and Meridius on Eddie's side and Black Widow, Sleeper, Red Goblin, and Flexo on Dylan's side.
Back in the present, Venom reveals that Lee Price has been revived as a zombiote and arrives at Peter Parker's apartment.
The next day, Flash attends a support group and receives a call from someone who invites him out for a drink as Carnage reunites with Cletus Kasady's clone.
At Investar, Carnage massacres its employees and, two weeks later, attacks a crowd of his followers at Ashford Park as soldiers armed with anti-symbiote weapons attempt to kill him.
[8] At Grand Garden Arena, wrestler Symbiote Smith issues a challenge to the Unlimited Class Wrestling Federation, with Crusher Hogan and Doc Sawbones serving as commentators.
After his future counterpart fades away, Toxin approaches Dylan and tells him of the events at Grand Garden Arena where Bedlam, Tyro, and Wilde have bested Paladin and his mercenaries.
At Alchemax, Liz holds an emergency meeting with Carlton Drake and Meridius regarding Eddie and learns of Chemical K-43, which is toxic to symbiotes.
After escaping from Alchemax, a horse bonded with a copy of the Venom symbiote thinks about "The Book of Simulacra and Simulation" as it compares the stages of simulacrums while on a rampage.
[10] Meridius infects Drake with a zombiote and fends of Liz Allan's Misery form before being approached by the Carnage symbiote, who had parted ways with Cletus Kasady's clone after a falling-out.
Meanwhile, the Venom Horse disrupts a performance at the Metropolitan Opera House while thinking about Scott McCloud and his understanding of comics.
Flexo and Red Goblin are revealed to have been manipulated by Doctor Doom and Kang the Conqueror, with the latter creating the Rascal symbiote from a fragment of Bedlam.
Meanwhile, the Venom Horse attacks a ball pit somewhere while wondering why people drive on a parkway and park on a driveway.
Later, the Carnage symbiote—bereft of its godly powers with All-Blood's destruction—approaches Eddie, who is now only human and gravely wounded, and considers bonding with him to survive.
He meets with his younger self and explains his mission to change the future before sedating Molten Man, who has escaped prison.
In flashbacks, Meridius blends in with life after being sent back in time and sees a younger Eddie Brock with his father Carl.
Carnage then bursts out of Finn's body and kills the security before Meridius ambushes him and informs him of a possible future involving mechanical Symbiotes.
[28] Sliver separates from Black Widow, but is possessed by a Zombiote and killed by Misery spreading the Anti-Venom cure through Alchemax.
After Wolverine wakes up in the presence of his old friend Emily Burke, the Zombiote that was on him resurrects the corpses at Baylight Cemetery as they are confronted by someone.
[36] Deadpool battles the Zombiotes in New York and is assisted by Andrea Benton / Silence and Princess, a dog-like clone of Carnage.
In the present, Liz Allan as Misery calls Silver Sable and the Wild Pack to New York to fight the Zombiotes.
At the Life Foundation building, Silver Sable then activates the Lethal Protector Mode on the devices planted on the Wild Pack's arms, causing them each to bond with a symbiote: Carl Striklan is possessed by Phage, Puma by Riot, Tarantula by Lasher, Navvab Tadjvar by Agony, Lightbright by Scream, and Lina Abbas by Flicker.
In response, the Pack destroys a Life Foundation tank containing Shriek, emitting a sonic burst that blasts the Zombiotes away.
Unable to fight the Zombiotes directly, the Wild Pack and Shriek flee to the Mississippi Queen and take command of it.
[41] In a flashback, Silver Sable describes the night her mother Anastasia was killed by German men to demonstrate her skilled memory and join the Wild Pack.
In the present with Dominic tied up, the Wild Pack prepares an Alchemax amplifier to channel Shriek's abilities and destroy the Zombiotes.
[42] As Elektra reflects on her life, she and Matt Murdock work as Daredevils to rescue the citizens from symbiotes and evacuate them to the Saint Nicholas Youth Center.
They succeed and trap the Kang variant "He Who Schemes" in a time loop with Doctor Doom's Schemebots as he vows to escape.