The tenth season of Family Guy premiered on the Fox network from September 25, 2011, to May 20, 2012 with a one-hour broadcast of two episodes.

During this season, Peter becomes friends with Ryan Reynolds (guest-voicing as himself), the Griffins win the lottery, Meg falls in love with an Amish boy as Peter goes to war with his family, Stewie starts driving Brian's car and accidentally crashes it, Meg dates Quagmire on her 18th birthday, Chris dates a girl who looks like Lois (voiced by Elliot Page), Quagmire asks Peter and Joe to help him kill his sister's (voiced by Kaitlin Olson) violently abusive boyfriend (voiced by Ralph Garman), Peter befriends a dolphin (voiced by Ricky Gervais[2]), Kevin Swanson (voiced by Scott Grimes) surprisingly returns to Quahog on Thanksgiving, Lois kidnaps Stewie's sick friend, Brian gets a blind girlfriend who hates dogs, James Woods makes a shocking return after being killed last season when Peter becomes an agent to Tom Tucker, Meg delivers a few home truths while scolding her family for all the abuse she personally suffered, Peter has another showdown with his mortal enemy, and Brian and Stewie travel back in time to the premiere Family Guy episode.

It was put on hold because of the 2011 Super Outbreak, which killed an estimated 346 people in the Southern United States around the time of the planned original release date.

TV said "Despite a one-hour finale event that delivered a few laughs, 'Viewer Mail #2 / Internal Affairs' tread far too much familiar ground, a problem that's been plaguing the series for some time now.

"[30] He continued, "There's a tipping point in TV sitcoms where the repeated use of a running joke stops being funny, and just seems lazy and uninspired.