The fifth season of Family Guy first aired on the Fox network in eighteen episodes from September 10, 2006, to May 20, 2007, before being released as two DVD box sets and in syndication.

The series follows the dysfunctional Griffin family—father Peter, mother Lois, daughter Meg, son Chris, baby Stewie and Brian, the family pet, who reside in their hometown of Quahog, a fictional city in the U.S. state of Rhode Island.

The executive producers for the fifth season were David Goodman, Chris Sheridan, Danny Smith and series creator Seth MacFarlane.

The season was executive produced by series regulars David A. Goodman, Seth MacFarlane, Chris Sheridan, and Danny Smith.

[7] As production began, Tom Devanney, Kirker Butler, Cherry Chevapravatdumrong, Alec Sulkin, Wellesley Wild, Patrick Meighan, Danny Smith, and future showrunners Mark Hentemann and Steve Callaghan[8] all stayed on from the previous season.

Mike Kim, James Purdum, Cyndi Tang, Greg Colton, Pete Michels, Zac Moncrief, John Holmquist and future Blue Harvest director Dominic Polcino all also stayed with the show from the previous season.

[39][40] The Parents Television Council, a frequent critic of Family Guy, branded "Stewie Loves Lois",[41] "Barely Legal",[42] "No Meals on Wheels",[43] and "Bill and Peter's Bogus Journey"[44] as the "worst show of the week."

In response to this criticism, executive producer David Goodman claimed that Family Guy is "absolutely for teenagers and adults", and that he does not allow his own children to watch the show.

[2] Haque also gave praise to "Blind Ambition", "No Chris Left Behind", "Bill and Peter's Bogus Journey", and "Meet the Quagmires".

"[46] In his review for the Family Guy volume five DVD, Francis Rizzo III of DVD Talk said "There are several points to criticize when it comes to this set, including a series that's losing some of its steam and relying on comedic crutches and an oddly constructed episode structure, but in the end, the series is fun to watch, which is all you really ask for from a cartoon sitcom.

"[48] The first thirteen episodes of the fifth season were released on DVD by 20th Century Fox in the United States and Canada on September 18, 2007, four months after they had completed broadcast on television.