The seventh season of Family Guy first aired on the Fox network from September 28, 2008, to May 17, 2009, before being released as two DVD box sets and syndicated.

The animated television series follows the dysfunctional Griffin family (father Peter, mother Lois, daughter Meg, son Chris, baby Stewie and their anthropomorphic dog Brian), who reside in the fictional town of Quahog, in the U.S. state of Rhode Island.

[14] Other producers included Mike Henry, Patrick Meighan, Tom Devanney, Alec Sulkin, Wellesley Wild, John L. Jacobs, Kara Vallow, Kirker Butler, Shannon Smith, Cherry Chevapravatdumrong, Kim Fertman and Brandi Young.

[16] The season had a number of secondary characters, including Lori Alan as Diane Simmons (a local news anchor);[17] Mike Henry as Cleveland Brown (a neighbor and friend of the Griffins); Patrick Warburton as Joe Swanson (a disabled neighbor)[18] and Jennifer Tilly as Bonnie Swanson (Joe's pregnant wife).

[20] Other recurring characters include Phil LaMarr as Ollie Williams,[21] Johnny Brennan as Mort Goldman, Carrie Fisher as Angela, Mark Hentemann as Opie, Borstein as Trisha Takanawa and Henry as Bruce.

The season also included guest actors voicing themselves, including Frank Sinatra Jr., Seth Rogen, Lauren Conrad, Johnny Knoxville, Jay Leno, Craig Ferguson, Audrina Patridge, Sinbad, Patrick Stewart, LeVar Burton, Gates McFadden, Brent Spiner, Michael Dorn, Jonathan Frakes, Wil Wheaton, Denise Crosby and Rob Lowe.

[46] Haque considered "Road to Germany" as the highlight of the season and regarded "The Juice is Loose" and "Baby Not On Board" as the poorest, citing them as examples of what the show could be when the writers "choose not to put in any effort".

[50] Casey Burchby from DVD Talk gave a mixed review to Volume Seven of Family Guy; he noted that while a lot of the jokes are obvious and not funny in the show's context, there are standout episodes such as "I Dream of Jesus" and "Baby Not On Board".

[1] Another writer from DVD Talk, Francis Rizzo III, reviewed Volume Eight and praised "Three Kings" for blending humor with the original films and its story-based narrative.

In response to its group's criticism, executive producer David Goodman claimed that Family Guy is "absolutely for adults" and he does not allow his own children to watch the show.

[64] The Venezuelan government reacted negatively to "420", and banned Family Guy from their local networks (which generally air syndicated American programming).

[2] Venezuelan Justice Minister Tareck El Aissami stated that any cable stations which refuse to stop airing the series would be fined, and he claimed that the program promoted the use of cannabis.

[65] Seth MacFarlane was nominated for a Primetime Emmy Award for Outstanding Voice-Over Performance for his role as Peter Griffin in "I Dream of Jesus".