FanDuel Sports Network Midwest is available on cable providers throughout eastern and central Missouri, Western and Southern Illinois, Nebraska, and Iowa; it is also available nationwide on satellite via DirecTV.

[3][4] The channel was then rebranded as Fox Sports Net Midwest in 1999, as part of a collective brand modification of the FSN networks under the "Fox Sports Net" banner; subsequently in 2004, the channel shortened its name to FSN Midwest, through the networks' de-emphasis of the brand.

In the spring of 2006, Fox Sports Midwest obtained the exclusive regional cable television rights to broadcast NBA games involving the Indiana Pacers.

In the fall of 2007, Fox Sports Midwest signed an exclusive long-term agreement to broadcast games from the Kansas City Royals (this followed the team's decision to dissolve the Royals Sports Television Network, a regional television syndication service for the team's game broadcasts).

On July 15, 2010, Fox Sports Midwest signed a new television contract with the St. Louis Cardinals, giving the channel exclusive regional broadcast rights to the team's games beginning with the 2011 season, ending the team's local broadcasts in the St. Louis market on NBC affiliate KSDK (channel 5).

On May 3, 2019, Sinclair Broadcast Group and Entertainment Studios (through their joint venture, Diamond Holdings) bought Fox Sports Networks from The Walt Disney Company for $10.6 billion.

[10] On November 17, 2020, Sinclair announced an agreement with casino operator Bally's Corporation to serve as a new naming rights partner for the FSN channels.

The channel also broadcasts college athletics, including men's basketball games from the Missouri Valley Conference and St. Louis Billikens.

It also filled a similar role for the Nebraska Cornhuskers until they joined the Big Ten Conference (which too has its own TV channel) in 2012, and like for Mizzou it aired university-produced ancillary programming for the Huskers.