KNSN-TV (channel 21) is a primary sports-formatted independent television station in Reno, Nevada, United States, which has a secondary affiliation with MyNetworkTV.

Sinclair also manages NBC affiliate KRNV-DT (channel 4) under a separate JSA with Cunningham Broadcasting; however, Sinclair effectively owns KRNV as the majority of Cunningham's stock is owned by the family of deceased group founder Julian Smith.

The three stations share studios on Vassar Street in Reno; KNSN-TV's transmitter is located on Red Hill between US 395 and SR 445 in Sun Valley, Nevada.

With the 2006 shutdown and merge of The WB and UPN to form The CW, the station joined News Corporation–owned and Fox sister network MyNetworkTV on September 5, 2006.

On July 20, 2012, one day after Cox Media Group purchased WAWS and WTEV in Jacksonville, Florida, and KOKI-TV and KMYT-TV in Tulsa, Oklahoma, from Newport Television, Cox put KRXI-TV (along with the LMA for KAME-TV) and sister stations WTOV-TV in Steubenville, Ohio, WJAC-TV in Johnstown, Pennsylvania, and KFOX-TV in El Paso, Texas (all in markets that are smaller than Tulsa), plus several radio stations in medium to small markets, on the selling block.