[4] She is said to have made her debut at the age of sixteen in 1818 in L'Italiana in Algeri of Gioacchino Rossini at the Teatro San Benedetto in Venice,[1] but she is listed in the printed libretto as having sung Achille in Ifigenia in Aulide by Simone Mayr in Florence during the spring of 1817.

[6] On December 15 of the following month, also at the Teatro San Luca, Eckerlin created the role of Enrico in Donizetti's Una follia, a now-lost opera buffa based on the same libretto as the previous work.

It was not a success; Bartolomeo Merelli, the librettist, later blamed Eckerlin in part for its failure, writing in his Cenni biografici that the piece had faltered due to the "caprices and ill will of several of the singers, especially the prima donna".

[11] During Eckerlin's career she spent several seasons at the Teatro Italiano in Barcelona, where a claque of her followers operated,[12] and where she won many favorable notices for her work before accepting a contract with the Salle Favart in Paris.

[4] She was a noted interpreter of Rossini,[1] and during his tenure at the helm of the Théâtre Italien she appeared there in a number of roles, among them creating Angelina in La cenerentola at its Paris premiere alongside Giovanni Battista Rubini and Fanny Tacchinardi Persiani.