Khan went onto star in the films Jungle (2000), Pyaar Tune Kya Kiya (2001), Bhoot (2003), Dev (2004), No Entry (2005), and All the Best (2009).

After a career decline with several critical and commercial failures, he appeared in Dulha Mil Gaya (2010), following which, he took a break from acting.

"[12] His career marked a turning point after he received critical recognition for the 2001 romantic thriller Pyaar Tune Kya Kiya.

Screen magazine noted, "Fardeen Khan as the happy-go-lucky photographer, is pleasing on the eye, light footed and comfortable with the part.

"[13] His other films of the year were the crime comedy Love Ke Liye Kuch Bhi Karega and the romantic drama Hum Ho Gaye Aapke, both box office failures.

[18] Film critic Taran Adarsh wrote, "Fardeen Khan registers an impact in a small but significant role.

[20] Bollywood Hungama noted, "Fardeen Khan springs a surprise by enacting a difficult role with flourish.

In December 2020, speculation arose that he may be planning a comeback to acting after being spotted outside the office of film director Mukesh Chhabra.

[26] Khan's comeback was confirmed when he announced having joined the cast of Akshay Kumar's Housefull 5, set to be released in 2025.