Barjatya made his directorial debut with the romantic musical Maine Pyar Kiya (1989) starring Salman Khan and Bhagyashree in lead roles.

Hum Aapke Hain Koun sold 74 million tickets in India, giving it the highest domestic footfalls of any Hindi film released since the 1990s.

He then collaborated with Khan for the third time for the family drama Hum Saath-Saath Hain (1999), which received mostly positive reviews from critics, and emerged as the highest-grossing Hindi film of the year.

[7][8] His fourth film was the musical romantic comedy Main Prem Ki Diwani Hoon (2003) starring Hrithik Roshan, Kareena Kapoor and Abhishek Bachchan in lead roles.

[9] His next film, the romantic drama Vivah (2006) starring Shahid Kapoor and Amrita Rao, however, emerged as one of the highest grossers of the year, despite mixed reviews.

[10] Post Vivah, he produced the romance Ek Vivaah... Aisa Bhi (2008) directed by Kaushik Ghatak, starring Isha Koppikar and Sonu Sood in lead roles.

[11] Following a 9-year directorial hiatus, he returned to direction with the romantic family drama Prem Ratan Dhan Payo (2015), which marked his fourth collaboration with Khan, alongside Sonam Kapoor.

[12] After another 7-year hiatus, his next directorial venture was the adventure drama Uunchai (2022) starring Amitabh Bachchan, Anupam Kher and Boman Irani with Parineeti Chopra.