The road, located in southeastern Reeves and northern Pecos counties, begins at U.S. Route 285 (US 285) near Pecos and intersects FM 1776, State Highway 18 (SH 18), and Ranch to Market Road 2593 (RM 2503) before terminating at FM 1053.

RM 2593 turns off the road to the north before the route ends at FM 1053.

[4] FM 1450 passes through agricultural land and encounters no cities or towns.

[1] That designation was short-lived, and was cancelled on February 15, 1950 when the route was combined with FM 27 as an extension.

On January 28, 1954, the route was extended to the Reeves County line and then to US 285 on September 29 of that year.