The road was originally designated in 1942 along the portion of the present route north of SH 21.

[2] SH 211 was extended north to Clay on January 26, 1935,[3] but on July 15, 1935, this extension was cancelled.

[1] FM 50 begins at SH 105 3.0 miles (4.8 km) northeast of Brenham in Washington County.

North of the creek, the road crosses the Burlington Northern and Santa Fe Railway at Clay.

The route then goes to the north largely following the Union Pacific Railroad through Law, Sims, an intersection with FM 1687 at Mudville, and Mooring.