It opened in 1851 as part of the Buckinghamshire Railway's branch line to Verney Junction which provided connections to Bletchley and Oxford and closed in 1963.

Situated in an isolated location over a mile from the village from which it took its name[4] - and further still from two others it was supposed to serve: Greatworth and Middleton Cheney[5] - Farthinghoe station first appeared in timetables in October 1851.

The main station building, a part-timber and part-brick structure in an "H" shape, was of unusual construction, with the main ticket office and booking hall housed in a one-storey weather-boarded wing with a steeply-pitched gable roof which projected over the platform as a sort of makeshift canopy.

[6] The station boasted limited goods facilities, with a cattle dock and weigh bridge provided for the mainly agricultural traffic.

[12] The meadow which adjoined the station and which was used for holding cattle and sheep prior to transfer to Banbury Market is now part of Farthinghoe Nature Reserve.