Fashion File was created and developed by Karen Morrison, who was the program Series Producer & Director.
The series was hosted from its inception until 2006 by Tim Blanks, who left the show at the end of 2006 to join the Canadian fashion magazine Flare as editor-at-large.
Over the winter of 2007, the Canadian Broadcasting Corporation aired Fashion File Host Hunt, a short-run reality show in which ten finalists competed to become the new host of the show.
Other contestants included Peter Papapetrou, Manny Neubacher, Justin Singh, Paul Pogue, Mary Kitchen, Stephanie Pigott, Jamey Ordolis, Raji Sohal and Henrietta Southam.
As of the end of March 2009, Fashion File was cancelled by CBC Television.