The Fast Healthcare Interoperability Resources (FHIR, /faɪər/, like fire) standard is a set of rules and specifications for the secure exchange of electronic health care data.

The standard describes data formats and elements (known as "resources") and an application programming interface (API) for exchanging electronic health records (EHR).

But it is easier to implement because it uses a modern web-based suite of API technology, including a HTTP-based RESTful protocol, and a choice of JSON, XML or RDF for data representation.

[17] The Sync for Science (S4S) profile builds on FHIR to help medical research studies ask for (and if approved by the patient, receive) patient-level electronic health record data.

[18] In January, 2018, Apple announced that its iPhone Health App would allow viewing a user's FHIR-compliant medical records when providers choose to make them available.

[20][21][22][23] In December 2014, a broad cross-section of US stakeholders committed to the Argonaut Project[24] which will provide acceleration funding and political will to publish FHIR implementation guides and profiles for query/response interoperability and document retrieval by May 2015.

[28] Experiences with developing medical applications using FHIR to link to existing electronic health record systems clarified some of the benefits and challenges of the approach, and with getting clinicians to use them.

[29] In 2020, the U.S. Centers for Medicare & Medicaid Services (CMS) issued their Interoperability and Patient Access final rule, (CMS-9115-F), based on the 21st Century Cures Act.

The rule requires the use of FHIR by a variety of CMS-regulated payers, including Medicare Advantage organizations, state Medicaid programs, and qualified health plans in the Federally Facilitated Marketplace by 2021.

Its first act was to create the IL-CORE work team in order to adapt the necessary components for localization and regulation in the health system in Israel.