[2] Touadéra subsequently served as rector of the university from 2005 to 2008, during which time he launched several key initiatives, such as the entrepreneurship training program and the creation of the Euclid Consortium.

[7] Touadéra was appointed prime minister by President François Bozizé on 22 January 2008, following the resignation of Élie Doté.

Later on the same day, his new 31-minister government was appointed, with only 10 ministers retaining their posts; many former rebels were included in the new line-up to prepare the country for the 2009 local elections and the 2010 presidential and parliamentary polls.

In his capacity as prime minister, Touadera signed the instrument of participation for the Central African Republic in May 2010.

[16][17] After he was sworn into office, France confirmed that it would end its military intervention in Central African Republic.

France had around 2,500 troops deployed in the country as part of Operation Sangaris, supporting about 10,000 United Nations peacekeepers.

[22] Touadéra's personal security detail is reportedly composed of members of the Russian Wagner Group.

[23] In July 2023, Touadéra attended the 2023 Russia–Africa Summit in Saint Petersburg and met Russian President Vladimir Putin.

[27] On February 10, 2025, Touadera announced the creation of $CAR as the country's official meme coin describing it as an "experiment" in national development.

[32] Both wives had reportedly been vying for the title of First Lady of the Central African Republic behind the scenes.