Castro graduated with a bachelor's degree in business administration in the UTH university ,and she grew up in Tegucigalpa; She married Zelaya in 1976 and became active in the women's section of the Liberal Party of Honduras.

Castro became involved in the National Popular Resistance Front after her husband's refusal to comply with a Supreme Court order led to the 2009 Honduran coup d'état, forcing him into exile.

At the 2017 Honduran general election, she was Salvador Nasralla's running mate, with the ticket narrowly losing to Hernández amidst allegations of irregularities.

She took part in the creation of the Centro de Cuidado Diurno para Niños en Catacamas (Children's Daily Care Center in Catacamas), with the aim of offering assistance to single-parent families led by women, including through the creation of projects of basic cleaning, sowing of vegetables, and floriculture as important projects of job development.

Lai Chien-Chung, the Taiwanese ambassador to Honduras, stating the refusal was to spread the risk and disputed the opposition's narrative of indifference.

Taiwanese KMT opposition member Tsai Cheng-Yuan claims that Taipei staff evicted the family and called in the military police to arrest them.

However, a general blackout interrupted the publication of the count for 36 hours; when it was restarted, the trend was reversed and President Juan Orlando Hernández was re-elected, leading to accusations of fraud.

[24] Polls showed a tight race between Castro and her right-wing opponent Nasry Asfura, of the incumbent National Party, a two-term mayor plagued by allegations of corruption.

[49] In May 2022, Castro began a measure passed by Congress to abolish Honduras' special economic zones, which the previous National government implemented.

[51] The bill was met with protests by melon farmers and shrimpers inside the country, because it entails a revocation of tax rebates for these industries.

[54] In her inaugural address, Castro announced to the nation that the largest base of the budget she will present to parliament is dedicated to salaries and wages.

[55] In-addition, Castro stated that she had ordered her Minister of Finance and the Central Bank to take action to reduce interest rates for production.

[56] Initially instituted for forty-five days in two municipalities, Tegucigalpa and San Pedro Sula, the state of exception has been renewed and extended to more than half of the country's cities.

[57] In February 2022, Deputy Foreign Minister Gerardo Torres Zelaya held a meeting with Sahrawi President Brahim Ghali, which concluded with an announcement that diplomatic relations between the peoples and governments of Honduras and the SADR had been restored and would be deepened.

[59][60] On 14 March 2023, Castro instructed her foreign minister to move to cut ties with Taiwan in order to establish formal relations with the People's Republic of China as the sole Chinese state.

[62] Retired Taiwanese Kuomintang opposition member Tsai Cheng-yuan (Alex) posted on social media that this move was a result of Taiwan refusing to shelter Castro during the 2009 coup.

[63][64][65] Castro for her part cited U.S. interventionism and pressure, especially in regards to Taiwan in Central America, as motives to open diplomatic relations with the People's Republic of China.

[66] Shortly following Castro's inauguration, an event attended by representatives of the Nicolás Maduro government,[67] the Venezuelan embassy in Honduras's capital of Tegucigalpa was vacated by representatives of Juan Guaidó,[citation needed] who had been recognised as the President of Venezuela by outgoing President Juan Orlando Hernández since the Venezuelan presidential crisis.

[citation needed] Former President and First Gentleman Manuel Zelaya responded to the news by sending a tweet welcoming Maduro, Latin American unity and the Bolivarian Revolution.

[74] Castro announced the recall of the Honduran ambassador from Israel on 4 November 2023, shortly after the country's ministry of foreign affairs stated that "Honduras energetically condemns the genocide and serious violations of international humanitarian law that the civilian Palestinian population is suffering in the Gaza Strip".