In 1969, he graduated from Sapienza University with a degree in mechanical engineering, and received a diploma in piano at the G. Rossini Conservatory in Pesaro in 1971, where he studied under Sergio Cafaro.

In the meantime, his older brothers took over the family business: a factory producing office furniture, using rare and exotic woods such as teak, mahogany and rosewood.

Paolo Fazioli joined the company as well; however, he never gave up on pursuing his dream of building the world's finest grand pianos.

Initial success followed in 1984 and 1985 when pianists including Aldo Ciccolini, Alfred Brendel, Martha Argerich, Vladimir Ashkenazy, Lazar Berman, Nikita Magaloff, Michel Beroff, Annie Fischer, Louis Lortie and many others began to play on Fazioli pianos.

The demand for an instrument having even greater power and richness of tone, for use in large concert halls, inspired the concept of the F308 model, which is presently the longest piano available on the market.

In 1996, a Fazioli was chosen for concerts in the Vienna Musikverein by Ingeborg Baldaszti, Markus Schirmer, Jasminka Stancul and Elisabeth Leonskaya.

In addition to standard black instruments, the company developed a series of unique art case models to cater to its most exacting customers.

The company's relationship with pianist Angela Hewitt became even more productive in 2003, when the artist began requesting Fazioli pianos for her world concert tours.

[5][6] In May, Louis Lortie used a Fazioli grand piano to perform a recital in place of Maurizio Pollini at Carnegie Hall in New York, earning glowing reviews.

In June 2010, in an interview with Michael Gallant of Keyboard magazine, Herbie Hancock talks about his Fazioli giving him inspiration to do things.

In July 2020, Nick Cave said that after playing a Fazioli in Idiot Prayer he became so enthusiastic about it that he contacted the company asking to receive one for free, but his request was rejected.

In the International Chopin Piano Competition in Warsaw (October, 2021) three of the 12 finalists played a Fazioli, including Bruce Liu, its winner.