It is located at Dewey Square, on the convergence of Fort Point and the Financial District neighborhoods.

In close proximity to the Boston Harbor, the Fort Point Channel and major intermodal South Station terminal, the building is marked by a distinctive opening near ground level which allows sea breezes to pass through.

[2] The design stood in contrast to that of the other Reserve Banks, which resembled fortresses.

[6][7] It features an auditorium that is named for Frank E. Morris, the President and Chief Executive Officer of the Federal Reserve Bank of Boston from 1968 to 1988.

[3] In the 2006 Martin Scorsese film The Departed, in the scene where Colin Sullivan (Matt Damon) gets caught on the roof by undercover cop Billy Costigan (Leonardo DiCaprio), the building can be seen in the background.