She and her sister began gymnastics at the age of 7 at the Andrea Doria Sports Club in Genoa, Italy.

[2] In December 2020, Alice and Asia received the Athlete of the Year award in the Liguria region of Italy.

[3][4] D'Amato made her international debut at the 2015 City of Jesolo Trophy as part of Italy's Young Dreams team alongside her twin sister Asia and Giorgia Villa.

[8] She later competed at the 2017 European Youth Olympic Festival alongside Elisa Iorio and Asia D'Amato.

[12] During the all-around final, D'Amato finished in fourth place after falling off the balance beam behind Mélanie de Jesus dos Santos of France, Ellie Downie of Great Britain, and Angelina Melnikova of Russia.

[14] In August, D'Amato competed at the Heerenveen Friendly, where she helped Italy win gold in the team competition ahead of the Netherlands and Norway, and individually, she finished fourth in the all-around behind Villa, Eythora Thorsdottir, and Naomi Visser.

They ended up finishing behind the United States and Russia, but ahead of China, who originally qualified to the final in second place.

[18] In early February, it was announced that D'Amato was selected to represent Italy at the Birmingham World Cup taking place in late March.

[21] In April, D'Amato was selected to represent Italy at the European Championships in Basel alongside Giorgia Villa, Martina Maggio, and Vanessa Ferrari.

D'Amato was later named to the team to compete at the World Championships in Liverpool alongside Maggio, Villa, Manila Esposito, Veronica Mandriota, and alternate Elisa Iorio.

D'Amato competed at the Cottbus World Cup where she finished first on uneven bars and fourth on floor exercise.

D'Amato next competed at the Cairo World Cup where she won gold on the uneven bars, and silver on floor exercise behind Joscelyn Roberson.

Her results in Cottbus and Cairo won her the World Cup series titles on both the uneven bars and floor exercise.

[32] D'Amato competed at the 2023 World Championships alongside Elisa Iorio, Angela Andreoli, Manila Esposito, and Arianna Belardelli; together they finished fifth as a team.

In November, D'Amato was awarded the Oscars of Brescia sport, alongside Roberto Rigali and Anna Danesi.

At the conclusion of the competition, she was named to the team to represent Italy at the 2024 Summer Olympics alongside Esposito, Andreoli, Iorio, and Giorgia Villa.