He studied at the University of Belgrade's Faculty of Arts, graduating in 1959 and completing a master's degree in political science in 1964.

[1] The authorities excluded him from teaching in 1981 and expelled him from the university during a purge of Kosovo Albanian academics following student riots.

[3] He headed Albanian delegations at talks leading up to the 1998–1999 Kosovo War and was one of the principal Kosovar negotiators at the Rambouillet Conference.

[1] A leading advocate of non-violence and reconciliation, he founded the Forum for Ethnic Relations with the aim of fostering a dialogue between Albanians and Serbs.

[2] The Kosovo Albanian philosopher Shkëlzen Maliqi later described Agani's role as being more of an independent actor and, in comparison to Rugova – who kept repeating the same dry phrases and promises – conducted active daily politics and directed the LDK's and the Albanian movement's ideological and strategic policy ... Agani was leading a pragmatic policy and managed the active part of the legalistic policy, balancing the tensions between the governing structures of the movement and the centres of power, that is, the parliament and government of Kosovo.