[1] [4] The function of the protein for cats is unknown, but it causes an IgG or IgE reaction in sensitive humans (either as an allergic or asthmatic response).
[7] Several other breeds are widely referenced as causing a diminished immune reaction in cat allergy sufferers, including Sphynx, Russian Blue, Cornish Rex, Devon Rex, Siamese, Javanese, Oriental shorthair, Burmese, and Laperm.
[1] Proteins matching the InterPro family signature for Fel d 1 parts is widespread among Theria, a subclass of mammals[8] amongst the Theriiformes (the sister taxon to Yinotheria.)
More specifically, the InterPro profiles link the two components of Fel d 1 to the rodent androgen-binding protein (ABP; not to be confused with the human SHBG), a salivary pheromone.
[11] The BGE possesses a protein resembling Fel d 1, which may affect host species as an allergen as a constituent of the venom.