Carlo Filippo Antonio Spinola y Colonna, 4th Marquis of the Balbases (Madrid, Spain, 11 November 1665 – 30 July 1721), was Viceroy of Sicily from 1707 to 1713, during the Spanish Succession War.
He was the eldest son of Paolo Spinola, 3rd Marquis of the Balbases, Governor of the Duchy of Milan from 1668 to 1670.
The eldest son, 5th Duke of Sesto and 5th Marquis of the Balbases from 1721, was Ambrosio Gaetano Spinola y de la Cerda (Milan, Italy, 20 January 1696 – 1757), who became a Knight of the Order of the Golden Fleece in 1737.
Spinola was the dedicatee of Tomaso Albinoni's 12 Concerti a cinque, Op.
5 (1707), and of Giacomo Facco's 12 Concerti a cinque "Pensieri Adriarmonici", Op.