In 2001, Colombo reprised his character inChiquititas' for the big screen version, Chiquititas: Rincón de luz.

However, Camila Bordonaba, Benjamín Rojas and Felipe Colombo reunited in 2006 and released the compilation of the greatest hits, El Disco de Rebelde Way.

In 2006, Colombo portrayed deceased Nirvana frontman Kurt Cobain in the stage play No te preocupes ojos azules.

He was seen in two films in 2008 Fantasma de Buenos Aires and Solos en la ciudad, alongside his Rebelde Way co-star Sabrina Garciarena.

In 2011–2012, his role is Bernardo Berlanga in Herederos de una venganza and 2012 he made Host TV debut in La vuelta al mundo together with the actress Isabel Macedo.

During the development of Rebelde Way, Felipe Colombo and his co-stars: Luisana Lopilato, Benjamín Rojas and Camila Bordonaba have become the members of the band Erreway.

In 2007, they did a concert in Valencia for Sunny Happy Day and received the Platinum Record for the 80,000 copies sold of his album Erreway, el disco de Rebelde way.

In 2010, he formed a new band, La Miss Tijuana with his friend Camila Bordonaba and Erreway's vocal coach, Willie Lorenzo.

Since 2007, Felipe Colombo has been in a relationship with Cecilia Coronado, a costume designer whom he met in the recordings of Son de Fierro.