[4] In 1949 Ayo first played as a soloist with the Bilbao Orkestra Sinfonikoa, subsequently working with the orchestra for 60 years.

[6] In 1970 Ayo formed the Quartetto Beethoven di Roma piano quartet,[1][3] with Alfonso Ghedin as violist, Mihai Dancila as cellist, and pianist Carlo Bruno,[7] because he wanted to turn to more Romantic repertoire.

[4] The Quartetto Beethoven di Roma, with innumerable tours in Europe, Russia, USA, Canada, South America, Australia, New Zealand, Japan, etc., and a continuous presence at international festivals, has been regarded as one of the finest chamber ensembles in the world.

[7] Ayo taught at the Accademia Nazionale di Santa Cecilia,[1][2][6] and held master classes in Denmark, Germany, Italy and Spain, Australia, Canada, the United States and Japan.

[4] A reviewer of the CD reissue noted in 1988, that they displayed an unusual relaxed freshness, and described Ayo's playing as lyrical.

[3] With I Musici he recorded more of Vivaldi's violin concertos[4] Corelli's concerti grossi, and works by Albinoni and Geminiani, among others.

[3] He recorded eight violin sonatas by Giovanni Battista Viotti with Corrado De Bernart, described by a reviewer as compositions of "grandeur, command and virtuosity", with a "compact command of lyricism and his gift for gracious turns of phrase"; he notes Ayo's "sweetly focused tone", summarising: "Here, in short, Viotti sings.