[1] Toward the end of autumn 1543, Felix entered the newly founded Capuchin friars as a lay brother at the Citta Ducale friary in the municipality of Anticoli Corrado.

In 1547 he was sent to Rome as quaestor of the Capuchin Friary of St. Bonaventure, where he spent his remaining 40 years begging alms to help in the friars' work of aiding the sick and the poor.

[2] In Rome, Brother Felix became a familiar sight, wandering barefoot through the streets, with a sack slung over his shoulders, knocking on doors to seek donations.

[5] He preached in the street, rebuked corrupt politicians and officials, and exhorted young men to stop leading dissolute lives.

[2] The plain-spoken Brother Felix was a good friend of St. Philip Neri and an acquaintance of Charles Borromeo.

[6] Felix died in Rome in 1587 on his 72nd birthday and was buried in the crypt of the Church of Santa Maria della Concezione dei Cappuccini.

A titular church in Rome was erected in his honor, San Felice da Cantalice a Centocelle In 19th-century Poland, the Felician Sisters, a religious congregation of Franciscan Sisters of the Third Order Regular, was founded to care for the poor and adopted him as their patron saint.