Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone.

It is added to some local anaesthetics such as prilocaine in a concentration of 0.03 IU/ml.

It will, however, have its main physiological effects on vascular SMC's due to the form in which it is administered.

The major points include the CNS, Liver, Anterior Pituitary, Muscle (both vascular and non-vascular smooth muscle), and Platelets (CLAMP).

Another example of a V1 agonist is terlipressin - which is used in oesophageal varices.