She became the first cyclist to officially be charged with mechanical doping, which arose from an incident that occurred at the 2016 UCI Cyclo-cross World Championships.

She was also active as a road cyclist and won the provincial time trial championships in the novices category in 2012 after finishing second in the same race the year before.

[4] In the 2015-16 cyclosross season Van den Driessche was beaten at the Koppenberg race by Jolien Verschueren in November 2015.

[5] Her race was interrupted as she had mechanical problems and electrical cables were observed hanging from her bike during a pit stop equipment check.

[8][9] Van den Driessche denies she intended to cheat, and maintains that the bicycle was owned by a friend and was taken to the pit in error.

[10][11][12] In the days following the incident, the friend in question, Nico Van Muylder, told Het Nieuwsblad that the bike was his.

[citation needed] Managing director Andrea Gastaldello said he was "stunned" by the news that Van den Driessche competed with a concealed motor in her Wilier Triestina bike, "Our company will take legal action against the athlete and against any (person) responsible for this very serious matter to safeguard the reputation and image of the company," he said.