Van den Eynde was born in Antwerp, into a wealthy family of artists and merchants.
The Van den Eynde were related by blood and marriage to several prominent Netherlandish artists, including Brueghel, Jode, and Lucas and Cornelis de Wael.
[5][1] Ferdinand van den Eynde was married to Susanna de Jode, aunt of Jan Brueghel.
[11][12] Two days before his death, Van den Eynde made his will, bequeathing his art collection to his brother Jan, who had meanwhile come to Italy and settled in Naples.
[12][13] Ferdinand van den Eynde was buried in the church of Santa Maria dell'Anima in Rome.